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It's important to note that semaglutide is not recommended for patients with severe gastrointestinal disease, including severe gastroparesis, as these conditions have not been studied in clinical trials and may be exacerbated by the medication's effects on gastric emptying

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Traditional treatments have centered on conservative measures such as manual lymphatic drainage and compression therapy, with surgery (such as lipedema liposuction) frequently being the most effective long-term solution